The Doctor & Cyberman
"Hello! Ooh, new teeth, that's weird..." And so Doctor 10 was born, with one of the most memorable lines in the show's history. It wouldn't be the 10th Doctor's most memorable line though; he was full of catchphrases, from 'Allons-y' to 'I'm so sorry' to 'Well...' (the link is well worth checking out for that last one by the way) and his final, heartbreaking line 'I don't want to go!'. Over 4 years on our screens he picked up quite a few verbal mannerisms, and quite a few enemies too: parallel world Cybermen, Ood, a newly-regenerated Master, Sontarans, and Vashta Nerada.
In his slim-fit suit, a swishy coat, and Converse All Stars, he was a Doctor far more in touch with humanity than any before or since. Perhaps its why David Tennant's excellent portrayal was so well received by fans and the public. His Doctor was one that could easily be related to, and his style much-admired by fans and fashionistas everywhere, but it does lead to the least alien portrayal of the Time Lord to date. But that fits in with the Doctor's story arc: he was a man who was used to humanity again, after his predecessor had been so detached from it.